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FOXP3 and Its Cofactors as Targets of Immunotherapies Review

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 115-121 doi: 10.1016/j.eng.2019.01.001

Abstract: <p>Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which areAs a consequence, the PTMs change the stability of FOXP3 and its capability to regulate gene expressionAlthough FOXP3 per se is not an ideal drug target, deacetylases, acetyltransferases, kinases, and other enzymes that regulate the PTMs of FOXP3 are potential targets to modulate FOXP3 and TregHowever, FOXP3 is not the only substrate for most of these enzymes; thus, unwanted "on target/off

Keywords： Treg     Forkhead box P3 (FOXP3)     Post-translational modification     Autoimmune     Cancer    

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Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 366-369 doi: 10.1007/s11684-008-0070-6

Abstract: The aim of this paper is to explore the effects of transfection of Foxp3 gene on the phenotype and functionThe pMSCV-Foxp3 retroviral vector encoding Foxp3 gene was transduced into the PT67 packaging cell lineFoxp3-gene transfected CD4 T cells could express Foxp3 and transfection of Foxp3 gene up-regulated theCD4CD25 T cells acquired a regulatory phenotype and function after it was transduced with the Foxp3 geneThis suggested a key role of Foxp3 in the generation of CD4CD25 regulatory T cells.
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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract: <p>The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediatingRecent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional targetrepressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signalingIntriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role inp>

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p

Frontiers of Medicine   Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related

Keywords： ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

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Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution

Yan-Gang ZHAO, Zhao-Hui LU

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 3,   Pages 315-322 doi: 10.1007/s11709-011-0117-7

Abstract: In this article, the third-moment reliability index, based on the three-parameter lognormal (3P-lognormal

Keywords： load and resistance factors     third-moment method     three-parameter lognormal (3P-lognormal) distribution    

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A comprehensive analysis of a 3-P (Pa) S spatial parallel manipulator

Yuzhe LIU,Liping WANG,Jun WU,Jinsong WANG

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 1,   Pages 7-19 doi: 10.1007/s11465-015-0324-3

Abstract: <p>In this paper, a novel 3-degree of freedom (3-DOF) spatial parallel kinematic machine (PKM) is analyzedp>

Keywords： parallel mechanism     concomitant motions     kinematics     workspaces     error model    

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RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: Moreover, previous studies confirmed that let-7c-5p, a well-known microRNA, can act as a tumour suppressorMoreover, RGS16 was validated as a direct target gene of miR let-7c-5p.The overexpression of miR let-7c-5p obviously downregulated the expression of RGS16, and knocking downmiR let-7c-5p had the opposite effect.Thus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and may

Keywords： RGS16     let-7c-5p     glioma     proliferation     migration    

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MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic

Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Lai Wei,Dorothy Ngo-Yin Fan,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 331-343 doi: 10.1007/s11684-015-0409-8

Abstract: In this study, miRNA profiling and qRT-PCR validation revealed that miR-142-3p and miR-142-5p were significantlyOverexpression of either miR-142-3p or miR-142-5p suppressed HCC cell migration, and overexpression ofboth synergistically inhibited cell migration, which indicated that miR-142-3p and miR-142-5p may cooperativelyregulate cell movement. miR-142-3p and miR-142-5p, which are mature miRNAs derived from the 3′Pathway enrichment analysis showed a strong association of the putative gene targets of miR-142-3p and

Keywords： hepatocellular carcinoma     microRNA     metastasis     cytoskeletal reorganization    

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Removal of P4, PH3 and H2S from Yellow Phosphoric Tail Gas by a Catalytic

Ning Ping,Hans-Jörg Bart,Wang Xueqian,Ma Liping,Chen Liang

Strategic Study of CAE 2005, Volume 7, Issue 6,   Pages 27-35

Abstract: <p>Yellow phosphorus tail gas is a resource to produce bulk chemicals, such as formate, oxalate, methanolproved to be effective catalysts in the catalytic oxidation process (COP) for H2S and PH33, total phosphorus＜ 5 mg/m3 was obtained by using the COP process.p>

Keywords： catalyst     catalytic oxidation     H2S     P4     PH3     fixed bed    

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Assessment of an alternative to deep foundations in compressible clays: the structural cell foundation

MARTÍNEZ-GALVÁN, Miguel P. ROMO

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 1,   Pages 67-80 doi: 10.1007/s11709-017-0399-5

Abstract: This type of foundation seems to be a highly competitive alternative to the friction pile-box foundationsappreciably smaller concrete volumes required for building the structural cell than the friction pile-boxConsidering these facts and others regarding scheduling, it was decided to replace 48-friction pile-box

Keywords： deep foundations     bearing capacity     resistant moment     structural cell     3D numerical modeling    

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Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4,   Pages 343-348 doi: 10.1007/s11705-007-0062-0

Abstract: An oxetane-derived monomer, 3-acryloyloxymethyl-3′-methyloxetane (AMO) was prepared from the reactionof 3-hydromethyl-3-methyloxetane with acryloyl chloride.The cationic ring-opening copolymerization of AMO with another oxetane-derived monomer, 3-(2-(2-(2-methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane (MEMO) was conducted in CHCl solution using BF3 ·OEt/1, 4-butanediol

Keywords： 4-butanediol     2-methoxyethylenoxy     consistent     oxetane-derived     copolymer    

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3D Modeling and Visualization of Virtual Construction Grou p

Zhang Zhengfeng,Fu Jinqiang,Zhang Fayu

Strategic Study of CAE 2007, Volume 9, Issue 5,   Pages 53-56

Abstract: <p style="text-align: justify;">3D modeling methods of terrain,  city structure,  highway and Taking into account the matching of 3D object with terrain model,  the visualization processesof digital city are analyzed. 3D modeling and visualization of residential district are realized.application shows that this approach has good adaptability and provides a new supplementary means for 3Dp>

Keywords： virtual construction group     3D modeling     visualization     terrain match    

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Optimization of cellulase production using

Saravanan P, Muthuvelayudham R, Rajesh Kannan R, Viruthagiri T

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 4,   Pages 443-452 doi: 10.1007/s11705-012-1225-1

Abstract: the optimum experimental conditions: pH (5.5), temperature (37.5°C), initial substrate concentration (3%Box-Behnken design (BBD) statistical tool and genetic algorithm (GA) are used to optimize the process

Keywords： cellulase     pineapple waste     Trichoderma reesei     Box-Behnken design     genetic algorithm    

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Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 95-99 doi: 10.1007/s11684-008-0017-y

Abstract: The Sj14-3-3 gene was amplified and subcloned into the expression vector pPICZ?The protein of rSj14-3-3 was prepared and purified and BALB/c mice were immunized which was followedThe Sj14-3-3 gene was expressed and secreted into the medium and its molecular weight was about 35000antibody and rSj14-3-3 had a promising immune reactivity.The recombinant Sj14-3-3 of eukaryotic expression in was successfully harvested.

Keywords： development     challenging     rSj14-3-3     resistance     cultural supernatant    

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Title Author Date Type Operation

FOXP3 and Its Cofactors as Targets of Immunotherapies

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Journal Article

Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p

Journal Article

Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution

Yan-Gang ZHAO, Zhao-Hui LU

Journal Article

A comprehensive analysis of a 3-P (Pa) S spatial parallel manipulator

Yuzhe LIU,Liping WANG,Jun WU,Jinsong WANG

Journal Article

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic

Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Lai Wei,Dorothy Ngo-Yin Fan,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong

Journal Article

Removal of P4, PH3 and H2S from Yellow Phosphoric Tail Gas by a Catalytic

Ning Ping,Hans-Jörg Bart,Wang Xueqian,Ma Liping,Chen Liang

Journal Article

Xiaohan: Traditional Chinese Medicine Talks About Health, Dietary Supplement and Improving Immunity (2020-3-

18 Apr 2022

Conference Videos

Assessment of an alternative to deep foundations in compressible clays: the structural cell foundation

MARTÍNEZ-GALVÁN, Miguel P. ROMO

Journal Article

Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Journal Article

3D Modeling and Visualization of Virtual Construction Grou p

Zhang Zhengfeng,Fu Jinqiang,Zhang Fayu

Journal Article

Optimization of cellulase production using

Saravanan P, Muthuvelayudham R, Rajesh Kannan R, Viruthagiri T

Journal Article

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Journal Article